Buraimoh Olubunmi Kazeem, Gbala Michael Olumide, Okeyemi Ajibade, Adeniyi Omotayo Oladele, Adegoke Abiodun Samuel, Daramola Alaba Olanrewaju, Olujobi Babatunde A, Adeyemo Mathew, Okurumeh Ogheneovo Ifedayo and Akinsipe Catherine Iyabo
Background: Effective pain management post-caesarean section is crucial for patient recovery. This study compares the side effects of intramuscular Nefopam-Diclofenac-Paracetamol versus Pentazocine-Diclofenac-Paracetamol combinations.
Methods: A prospective, randomized, double-blind trial was conducted at the University of Medical Sciences Teaching Hospital, Ondo City, Nigeria, from June to October 2022. A total of 140 patients undergoing elective or emergency Caesarean sections were randomized into two groups: Group A (Nefopam 20 mg) and Group B (Pentazocine 30 mg), both receiving IV paracetamol 1 g and IM diclofenac 75 mg. Side effects such as nausea, vomiting, and dizziness were recorded over 24 hours. Data were analyzed using SPSS version 22, with significance set at p<0.05.
Results: Of the participants, 10.0% in the Pentazocine group and 4.3% in the Nefopam group reported nausea (p = 0.326). Vomiting occurred in 5.7% of the Pentazocine group and 2.9% of the Nefopam group (p = 0.681). Dizziness was reported by 7.1% in the Pentazocine group and 2.9% in the Nefopam group (p = 0.441). No significant differences were observed between groups.
Conclusion: Both Nefopam and Pentazocine combinations were associated with minimal side effects. However, pain assessment was not included, warranting further studies to evaluate analgesic efficacy.
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