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International Journal of Gynaecology and Obstetrics Sciences

Vol. 7, Issue 1, Part A (2025)

Evaluating the safety and side effect profiles of Nefopam-diclofenac-paracetamol vs. Pentazocine-diclofenac-paracetamol in post-caesarean Analgesia: A randomized double-blind study

Author(s):

Buraimoh Olubunmi Kazeem, Gbala Michael Olumide, Okeyemi Ajibade, Adeniyi Omotayo Oladele, Adegoke Abiodun Samuel, Daramola Alaba Olanrewaju, Olujobi Babatunde A, Adeyemo Mathew, Okurumeh Ogheneovo Ifedayo and Akinsipe Catherine Iyabo

Abstract:

Background: Effective pain management post-caesarean section is crucial for patient recovery. This study compares the side effects of intramuscular Nefopam-Diclofenac-Paracetamol versus Pentazocine-Diclofenac-Paracetamol combinations.

Methods: A prospective, randomized, double-blind trial was conducted at the University of Medical Sciences Teaching Hospital, Ondo City, Nigeria, from June to October 2022. A total of 140 patients undergoing elective or emergency Caesarean sections were randomized into two groups: Group A (Nefopam 20 mg) and Group B (Pentazocine 30 mg), both receiving IV paracetamol 1 g and IM diclofenac 75 mg. Side effects such as nausea, vomiting, and dizziness were recorded over 24 hours. Data were analyzed using SPSS version 22, with significance set at p<0.05.

Results: Of the participants, 10.0% in the Pentazocine group and 4.3% in the Nefopam group reported nausea (p = 0.326). Vomiting occurred in 5.7% of the Pentazocine group and 2.9% of the Nefopam group (p = 0.681). Dizziness was reported by 7.1% in the Pentazocine group and 2.9% in the Nefopam group (p = 0.441). No significant differences were observed between groups.

Conclusion: Both Nefopam and Pentazocine combinations were associated with minimal side effects. However, pain assessment was not included, warranting further studies to evaluate analgesic efficacy.

Pages: 08-13  |  90 Views  39 Downloads


International Journal of Gynaecology and Obstetrics Sciences
How to cite this article:
Buraimoh Olubunmi Kazeem, Gbala Michael Olumide, Okeyemi Ajibade, Adeniyi Omotayo Oladele, Adegoke Abiodun Samuel, Daramola Alaba Olanrewaju, Olujobi Babatunde A, Adeyemo Mathew, Okurumeh Ogheneovo Ifedayo and Akinsipe Catherine Iyabo. Evaluating the safety and side effect profiles of Nefopam-diclofenac-paracetamol vs. Pentazocine-diclofenac-paracetamol in post-caesarean Analgesia: A randomized double-blind study. Int. J. Gynaecol. Obstet. Sci. 2025;7(1):08-13. DOI: 10.33545/26649004.2025.v7.i1a.33