Vol. 6, Issue 1, Part A (2024)

Background: The preferred therapy for subfertility caused by non-tubal reasons is intrauterine insemination (IUI). For this reason, injectable gonadotropins are the recommended extra strategy for promoting ovarian follicle growth during IUI cycles. Mature, developing follicles emit the hormones estrogen and progesterone, which causes endometrial thickness (ET). ET is often used as supplemental stimulation to encourage ovarian follicle development during IUI cycles. Progesterone and estrogen are produced by the developing follicles, which causes endometrial thickness and proliferation.

Aim of the Study: To investigate the effect of ET on clinical pregnancy rate on IUI stimulated cycles.

Patients, Materials and Methods: The study was included seventy-four women who were agreed to use letrizole-gonadotropin IUI cycles in private clinic at Wasit Province from June 2020 to June 2022. Positive and negative cycles were compared in terms of mean endometrial thickness. After that, ET values were separated into two groups: 7.0–10 mm and >10 mm. Version 22 of the Statistical Package for Social Sciences (SPSS) was used to analyze the data. ANOVA, independent sample t-tests, chi square tests, and Fisher's exact tests were used in the main investigation of the effect of ET on the clinical pregnancy rate.

Results: The study population included 74 IUI cycles, which corresponded to 74 patients and had a clinical pregnancy rate of 27%. The mean ET for cycles that resulted in clinical pregnancy and those did not achieve pregnancy did not vary significantly. The two groups of ETs were significantly different from one another (P=0.031), with the greatest incidence of clinical pregnancy occurring between 7 and 10 mm. The size, number of dominant follicles, and progesterone level on the day of trigger (P=0.013), (P=0.003), and (P=0.000) are additional parameters that have a substantial impact on conception.

Conclusion: In addition to having a numerical trend toward greater clinical pregnancy rates, ET in the 7–10 mm range was significantly more successful in increasing conception rates. Positive predictors include the size and number of dominant follicles, and progesterone levels on the day of trigger. In contrast, ET was found to be a poor predictor of IUI pregnancy rates and it is not suitable to rely it as the only indication for cycle cancellation. To ascertain if the results of this study are genuine, further investigation is required.